产品货号：
Z26958
中文名称：
SOD2抗体
英文名称：
Anti-SOD2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SOD2 Antibody |
| 指标别名 | IPO B;Mn SOD;MNSOD;SOD2;SODM |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC |
| 基因名称 | SOD2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human SOD2(45-62aa QIMQLHHSKHHAAYVNNL),identical to the related mouse sequence and different from the related rat sequence by one amino acid. |
| 实际分子量 | 24KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | SOD2(Superoxide Dismutase 2),also called IPO-B or MNSOD,is a mitochondrial matrix enzyme that scavenges oxygen radicals produced by the extensive oxidation-reduction and electron transport reactions occurring in mitochondria.This gene is a member of the iron/manganese superoxide dismutase family.Using a somatic cell hybrid panel containing different segments of chromosome 6,they demonstrated that SOD2 is located in the region 6q25.3-qter which,together with the FISH analysis,indicated that SOD2 is in the distal portion of 6q25.The SOD2 gene encodes an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation.Adeno-associated viral delivery of the human SOD2 gene resulted in suppression of optic nerve degeneration and rescue of retinal ganglion cells.The findings suggested that reactive oxygen species contributed to retinal cell death and optic nerve damage in mice with complex I deficiency,and that expression of SOD2 attenuated the disease process. |
| Uniprot ID | P04179 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | superoxide dismutase 2,mitochondrial |
| 蛋白名全称 | Superoxide dismutase[Mn],mitochondrial |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry in fixed cells (ICC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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